Bronchodilating action of (-)-1(3, 4, 5-trimethoxybenzyl)-7-hydroxy-1, 2, 3, 4-tetrahydroisoquinoline HCl (l-MTI)

Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines

A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...

Microwave assisted synthesis of [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazine Derivatives

New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the con...

Bronchodilating actions of (+/-)-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline (TMI) derivatives in anesthetized cats.

Bronchodilating actions of 7-hydroxy(l), 5,7-dihydroxy(II), 5,6,7-trihydroxy (III) and 6,7.ti-trihvdroxy(IV)-(_~ )-I-(3,4,5-trimethoxybenzyl)-12,3,4-tetrahydroiso quinolinc (TMl) sere investigated in anesthetii.ed cats and results were compared to those of AQ-110 (6,7-dih)droxy-TMI) and isoproterenol. TMI derivatives given intravenously suppressed the bronchoconstriction induced by serotonin. T...

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